Endocrine Abstracts

Objective: The human androgen recteptor (AR) contains a polyglutamine and a polyglycine stretch that are highly polymorphic and are coded by a CAG and GGN repeat, respectively, in exon 1 of the AR gene. Although in vitro studies indicated a possible effect on AR gene tanscription and clinical observations suggest a modulation of androgen action, the functional significance of the GGN repeat remains unclear.We wanted to assess whether the GGN repea...

Sex hormone binding globulin (SHBG) is a plasma glycoprotein responsible for high-affinity binding and transport of sex steroids. In men there is a large interindividual variation of SHBG levels, and consequently of serum total testosterone (T) and serum total estradiol (E2) levels. Family and twin studies suggested a strong genetic contribution to this variation, besides a hormonal and metabolic influence. The aim of this study was to examine the influence of a missense mutat...

Background: In elderly men, fracture risk is independently associated with higher serum sex hormone-binding globulin (SHBG) levels1. Previously, we observed lower free estradiol (E2) and higher SHBG levels in a three-generational family study of men with idiopathic osteoporosis2.Objective: To investigate associations between serum SHBG levels and cortical bone size at age of peak bone mass.Design: S...